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KMID : 0355419950190040447
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Journal of Korean Academy of Oral Health
1995 Volume.19 No. 4 p.447 ~ p.456
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Effect of Phellodendri cortex L. on the Activity of Glucosyltransferase and Human Gingival Cell, Growth and Membrane Permeability of Streptococcus mutans JC-2
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Abstract
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We investigated the effects of phellodendri cortex L. on the activity of glucosyltransferase and human gingival cells growth and membrane permeability of Streptococcus mutans JC-2. The water extract of phellodendri cortex l. inhibited the
activity
of
glucosyltransferase which produced by Streptococcus mutans JC-2 and then showed 40.8, 63.3 and 72.1% inhibition rate at 500, 1000 and 2000ppm of concentration, respectively. Cytosolic components of Streptococcus mutans JC-2 were leakaged
significantly
about five times control amoumt by adding 2000ppm of Phellodendri cortex L. because of the injury of plasma mem-brane permeability. The relative activity of human gingival cells showed 83.65, 76.78 and 2.92% at 500, 100 and 200ppm of
concentration,
respectively. The antimicrobial compents of Phellodendri cortex l. were extracted by hexane and ethylether.
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